Mayra F.B
The preferred animal model for allergic bronchial asthma to assess anti-asthmatic drugs is the guinea pig; since the airway anatomy and the response to inflammatory is similar to humans. A strength of the model is the direct anaphylactic bronchoconstriction upon antigen challenge. Under certain conditions a late asthmatic response can be measured and airway hyper responsiveness is observed in vitro and in vivo. Aswell to inflammatory response is homologous with human situation. More recent studies describe a chronic model for asthma in which airway remodeling is induced as can be observed in the asthmatic patients. The focus here is to demonstrate that guinea pig asthma models are useful for testing novel therapeutics.
The preferred animal model for allergic bronchial asthma to assess anti-asthmatic drugs is the guinea pig; since the airway anatomy and the response to inflammatory is similar to humans. A strength of the model is the direct anaphylactic bronchoconstriction upon antigen challenge. Under certain conditions a late asthmatic response can be measured and airway hyper responsiveness is observed in vitro and in vivo. Aswell to inflammatory response is homologous with human situation. More recent studies describe a chronic model for asthma in which airway remodeling is induced as can be observed in the asthmatic patients. The focus here is to demonstrate that guinea pig asthma models are useful for testing novel therapeutics.
Key Words:
In Vitro: studies are performed with microorganisms, cells, or biological molecules outside their normal biological context
In Vivo: performed or taking place in a living organism
APA Citation: Ricciardolo, F. L., Nijkamp, F., De, V., & Folkerts, G. (2008, June). The guinea pig as an animal model for asthma. Retrieved April 25, 2017, from https://www.ncbi.nlm.nih.gov/pubmed/18537584
In Vitro: studies are performed with microorganisms, cells, or biological molecules outside their normal biological context
In Vivo: performed or taking place in a living organism
APA Citation: Ricciardolo, F. L., Nijkamp, F., De, V., & Folkerts, G. (2008, June). The guinea pig as an animal model for asthma. Retrieved April 25, 2017, from https://www.ncbi.nlm.nih.gov/pubmed/18537584